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The model of biological computation of ITDs proposed by Jeffress extracts ITDs by means of delay lines and coincidence detecting neurons:

The peaks of the sound pressure at each ear lead, via a semi-mechanical process, to peaks in the activity of certain auditory nerve fibers. Those fibers connect to coincidence-detecting neurons. Different delays in connections from the two ears lead to coincidence for different ITDs, thus making these coincidence-detecting neurons selective for different angles to the sound source.