Show Reference: "Alignment of Multimodal Sensory Input in the Superior Colliculus through a Gradient-Matching Mechanism"

Alignment of Multimodal Sensory Input in the Superior Colliculus through a Gradient-Matching Mechanism The Journal of Neuroscience, Vol. 32, No. 15. (11 April 2012), pp. 5264-5271, doi:10.1523/jneurosci.0240-12.2012 by Jason W. Triplett, An Phan, Jena Yamada, David A. Feldheim
@article{triplett-et-al-2012,
    abstract = {The superior colliculus ({SC}) is a midbrain structure that integrates visual, somatosensory, and auditory inputs to direct head and eye movements. Each of these modalities is topographically mapped and aligned with the others to ensure precise behavioral responses to multimodal stimuli. While it is clear that neural activity is instructive for topographic alignment of inputs from the visual cortex (V1) and auditory system with retinal axons in the {SC}, there is also evidence that activity-independent mechanisms are used to establish topographic alignment between modalities. Here, we show that the topography of the projection from primary somatosensory cortex (S1) to the {SC} is established during the first postnatal week. Unlike {V1–SC} projections, the {S1–SC} projection does not bifurcate when confronted with a duplicated retinocollicular map, showing that retinal input in the {SC} does not influence the topography of the {S1–SC} projection. However, {S1–SC} topography is disrupted in mice lacking {ephrin-As}, which we find are expressed in graded patterns along with their binding partners, the {EphA4} and {EphA7}, in both S1 and the somatosensory recipient layer of the {SC}. Together, these data support a model in which somatosensory inputs into the {SC} map topographically and establish alignment with visual inputs in the {SC} using a gradient-matching mechanism.},
    author = {Triplett, Jason W. and Phan, An and Yamada, Jena and Feldheim, David A.},
    day = {11},
    doi = {10.1523/jneurosci.0240-12.2012},
    issn = {1529-2401},
    journal = {The Journal of Neuroscience},
    keywords = {alignment, biology, development, localization, multi-modality, sc, sc-input, somatosensation},
    month = apr,
    number = {15},
    pages = {5264--5271},
    posted-at = {2012-04-12 11:18:01},
    priority = {2},
    publisher = {Society for Neuroscience},
    title = {Alignment of Multimodal Sensory Input in the Superior Colliculus through a {Gradient-Matching} Mechanism},
    url = {http://dx.doi.org/10.1523/jneurosci.0240-12.2012},
    volume = {32},
    year = {2012}
}

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There are projections from primary somatosensory cortex to SC.

Primary somatosensory cortex is somatotopic.