Show Reference: "Deficits in Eye Movements Following Frontal Eye-Field and Superior Colliculus Ablations"

Deficits in Eye Movements Following Frontal Eye-Field and Superior Colliculus Ablations Journal of Neurophysiology, Vol. 44, No. 6. (01 December 1980), pp. 1175-1189 by Peter H. Schiller, Sean D. True, Janet L. Conway
@article{schiller-et-al-1980,
    abstract = {1. This study investigated the effects of frontal eye-field and superior colliculus ablations on fixation patterns and saccadic eye movements. Monkeys were trained to pick apple pieces out of a multiple-slotted apple board while their heads were fixed. Eye movement records were obtained using predominantly the implanted search-coil method. 2. Both unilateral and bilateral frontal eye-field lesions produced only temporary deficits in eye movements. Following surgery monkeys tended to neglect the contralateral peripheral visual field and made fewer saccades to peripheral targets. Recovery was virtually completed in 2-4 wk. 3. Superior colliculus ablation reduced fixation accuracy, saccade frequency, and saccade velocity. These deficits showed little recovery with time. 4. Paired frontal eye-field and superior colliculus lesions produced dramatic deficits in visually triggered eye movements. Animals could no longer fixate their eyes on visual targets with any degree of accuracy. The range of eye movements was greatly reduced, as was the frequency and velocity of saccades. These deficits showed little recovery with time. 5. These results suggest that visually triggered saccadic eye movements are controlled by two parallel channels, one involving the superior colliculus and the other the frontal eye field.},
    author = {Schiller, Peter H. and True, Sean D. and Conway, Janet L.},
    citeulike-article-id = {8604550},
    citeulike-linkout-0 = {http://jn.physiology.org/content/44/6/1175.abstract},
    citeulike-linkout-1 = {http://jn.physiology.org/content/44/6/1175.full.pdf},
    citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/6778974},
    citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=6778974},
    day = {01},
    issn = {1522-1598},
    journal = {Journal of Neurophysiology},
    keywords = {biology, fef, saccades, sc},
    month = dec,
    number = {6},
    pages = {1175--1189},
    pmid = {6778974},
    posted-at = {2015-01-06 09:31:40},
    priority = {2},
    publisher = {American Physiological Society},
    title = {Deficits in Eye Movements Following Frontal {Eye-Field} and Superior Colliculus Ablations},
    url = {http://jn.physiology.org/content/44/6/1175.abstract},
    volume = {44},
    year = {1980}
}

See the CiteULike entry for more info, PDF links, BibTex etc.

FEF stimulation elicits saccadic eye movements.

"SC ablation permanently reduces fixation accuracy, saccade frequency, and saccade velocity."

FEF ablation leads to a temporary visual neglect. This neglect disappears almost completely after a short time.

Removing both SCs and both FEFs leads to permanent deficits:

  • a decrease in fixation accuracy,
  • a neglect of the peripheral visual field,
  • saccade frequency is decreased,
  • the range of saccadic eye movements is reduced.

Schiller et al. did not observe the visuospatial neglect and stark loss of oculomotor function as did Sprague and Meikle.