Show Reference: "Precise Lamination of Retinal Axons Generates Multiple Parallel Input Pathways in the Tectum"

Precise Lamination of Retinal Axons Generates Multiple Parallel Input Pathways in the Tectum The Journal of Neuroscience, Vol. 33, No. 11. (13 March 2013), pp. 5027-5039, doi:10.1523/jneurosci.4990-12.2013 by Estuardo Robles, Alessandro Filosa, Herwig Baier
@article{robles-et-al-2013,
    abstract = {The axons of retinal ganglion cells ({RGCs}) form topographic connections in the optic tectum, recreating a two-dimensional map of the visual field in the midbrain. {RGC} axons are also targeted to specific positions along the laminar axis of the tectum. Understanding the sensory transformations performed by the tectum requires identification of the rules that control the formation of synaptic laminae by {RGC} axons. However, there is little information regarding the spatial relationships between multiple axons as they establish laminar and retinotopic arborization fields within the same region of neuropil. Moreover, the contribution of {RGC} axon lamination to the processing of visual information is unknown. We used Brainbow genetic labeling to visualize groups of individually identifiable axons during the assembly of a precise laminar map in the larval zebrafish tectum. Live imaging of multiple {RGCs} revealed that axons target specific sublaminar positions during initial innervation and maintain their relative laminar positions throughout early larval development, ruling out a model for lamina selection based on iterative refinements. During this period of laminar stability, {RGC} arbors undergo structural rearrangements that shift their relative retinotopic positions. Analysis of cell-type-specific lamination patterns revealed that distinct combinations of {RGCs} converge to form each sublamina, and this input heterogeneity correlates with different functional responses to visual stimuli. These findings suggest that lamina-specific sorting of retinal inputs provides an anatomical blueprint for the integration of visual features in the tectum.},
    author = {Robles, Estuardo and Filosa, Alessandro and Baier, Herwig},
    day = {13},
    doi = {10.1523/jneurosci.4990-12.2013},
    issn = {1529-2401},
    journal = {The Journal of Neuroscience},
    keywords = {biology, retina, sc, visual, visual-processing},
    month = mar,
    number = {11},
    pages = {5027--5039},
    pmid = {23486973},
    posted-at = {2013-11-28 09:21:36},
    priority = {2},
    publisher = {Society for Neuroscience},
    title = {Precise Lamination of Retinal Axons Generates Multiple Parallel Input Pathways in the Tectum},
    url = {http://dx.doi.org/10.1523/jneurosci.4990-12.2013},
    volume = {33},
    year = {2013}
}

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Different types of retinal ganglion cells project to different lamina in the zebrafish optic tectum.

The lamina a retinal ganglion cell projects to in the zebrafish optic tectum does not change in the fish's early development. This is in contrast with other animals.

However, the position within the lamina does change.