# Show Reference: "All-or-none potentiation at CA3-CA1 synapses"

All-or-none potentiation at CA3-CA1 synapses Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 8. (14 April 1998), pp. 4732-4737 by Carl C. Petersen, Robert C. Malenka, Roger A. Nicoll, John J. Hopfield
@article{petersen-et-al-1998,
abstract = {The molecular mechanisms underlying long-term potentiation in the hippocampus have received much attention because of the likely functional importance of synaptic plasticity for information storage and the development of neuronal connectivity. Surprisingly, it remains unclear whether activity modifies the strength of individual synapses in a digital (all-or-none) or analog (graded) manner. Here we characterize step-like all-or-none transitions from baseline synaptic transmission to potentiated states following protocols for inducing potentiation at putative single {CA3}-{CA1} synaptic connections. Individual synapses appear to have all-or-none potentiation indicative of highly cooperative processes but different thresholds for undergoing potentiation. These results raise the possibility that some forms of synaptic memory may be stored in a digital manner in the brain.},
author = {Petersen, Carl C. and Malenka, Robert C. and Nicoll, Roger A. and Hopfield, John J.},
day = {14},
issn = {0027-8424},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
keywords = {binary, biology, learning, synapses},
month = apr,
number = {8},
pages = {4732--4737},
pmcid = {PMC22559},
pmid = {9539807},
posted-at = {2013-11-04 10:52:48},
priority = {2},
title = {All-or-none potentiation at {CA3}-{CA1} synapses},
url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC22559/},
volume = {95},
year = {1998}
}


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