Show Reference: "Modeling Cross-Modal Enhancement and Modality-Specific Suppression in Multisensory Neurons"

Modeling Cross-Modal Enhancement and Modality-Specific Suppression in Multisensory Neurons Neural Computation, Vol. 15, No. 4. (1 April 2003), pp. 783-810, doi:10.1162/08997660360581903 by Paul E. Patton, Thomas J. Anastasio
@article{patton-and-anastasio-2003,
    abstract = {Cross-modal enhancement ({CME}) occurs when the neural response to a stimulus of one modality is augmented by another stimulus of a different modality. Paired stimuli of the same modality never produce supra-additive enhancement but may produce modality-specific suppression ({MSS}), in which the response to a stimulus of one modality is diminished by another stimulus of the same modality. Both {CME} and {MSS} have been described for neurons in the deep layers of the superior colliculus ({DSC}), but their neural mechanisms remain unknown. Previous investigators have suggested that {CME} involves a multiplicative amplifier, perhaps mediated by N-methyl D-aspartate ({NMDA}) receptors, which is engaged by cross-modal but not modality-specific input. We previously postulated that {DSC} neurons use multisensory input to compute the posterior probability of a target using Bayes' rule. The Bayes' rule model reproduces the major features of {CME}. Here we use simple neural implementations of our model to simulate both {CME} and {MSS} and to argue that multiplicative processes are not needed for {CME}, but may be needed to represent input variance and covariance. Producing {CME} requires only weighted summation of inputs and the threshold and saturation properties of simple models of biological neurons. Multiplicative nodes allow accurate computation of posterior target probabilities when the spontaneous and driven inputs have unequal variances and covariances. Neural implementations of the Bayes' rule model account better than the multiplicative amplifier hypothesis for the effects of pharmacological blockade of {NMDA} receptors on the multisensory responses of {DSC} neurons. The neural implementations also account for {MSS}, given only the added hypothesis that input channels of the same modality have more spontaneous covariance than those of different modalities.},
    address = {Beckman Institute, University of Illinois at Urbana/Champaign, 61801, USA. ppatton@uiuc.edu},
    author = {Patton, Paul E. and Anastasio, Thomas J.},
    citeulike-article-id = {403899},
    citeulike-linkout-0 = {http://dx.doi.org/10.1162/08997660360581903},
    citeulike-linkout-1 = {http://www.mitpressjournals.org/doi/abs/10.1162/08997660360581903},
    citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12689387},
    citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12689387},
    day = {1},
    doi = {10.1162/08997660360581903},
    issn = {0899-7667},
    journal = {Neural Computation},
    month = apr,
    number = {4},
    pages = {783--810},
    pmid = {12689387},
    posted-at = {2011-07-21 13:50:38},
    priority = {2},
    publisher = {MIT Press},
    title = {Modeling {Cross-Modal} Enhancement and {Modality-Specific} Suppression in Multisensory Neurons},
    url = {http://dx.doi.org/10.1162/08997660360581903},
    volume = {15},
    year = {2003}
}

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Enhancement in the SC happens only between stimuli from different modalities.

Patton and Anastasio present a model of "enhancement and modality-specific suppression in multi-sensory neurons" that requires no multiplicative interaction. It is a follow-up of their earlier functional model of these neurons which requires complex computation.