Show Reference: "Multisensory Integration in Macaque Visual Cortex Depends on Cue Reliability"

Multisensory Integration in Macaque Visual Cortex Depends on Cue Reliability Neuron, Vol. 59, No. 4. (28 August 2008), pp. 662-673, doi:10.1016/j.neuron.2008.06.024 by Michael L. Morgan, Gregory C. DeAngelis, Dora E. Angelaki
@article{morgan-et-al-2008,
    abstract = {Responses of multisensory neurons to combinations of sensory cues are generally enhanced or depressed relative to single cues presented alone, but the rules that govern these interactions have remained unclear. We examined integration of visual and vestibular self-motion cues in macaque area {MSTd} in response to unimodal as well as congruent and conflicting bimodal stimuli in order to evaluate hypothetical combination rules employed by multisensory neurons. Bimodal responses were well fit by weighted linear sums of unimodal responses, with weights typically less than one (subadditive). Surprisingly, our results indicate that weights change with the relative reliabilities of the two cues: visual weights decrease and vestibular weights increase when visual stimuli are degraded. Moreover, both modulation depth and neuronal discrimination thresholds improve for matched bimodal compared to unimodal stimuli, which might allow for increased neural sensitivity during multisensory stimulation. These findings establish important new constraints for neural models of cue integration.},
    author = {Morgan, Michael L. and DeAngelis, Gregory C. and Angelaki, Dora E.},
    day = {28},
    doi = {10.1016/j.neuron.2008.06.024},
    issn = {1097-4199},
    journal = {Neuron},
    keywords = {biology, cue-combination, multi-modality, population-coding, visual},
    month = aug,
    number = {4},
    pages = {662--673},
    pmid = {18760701},
    posted-at = {2012-08-17 16:41:46},
    priority = {2},
    publisher = {Cell Press},
    title = {Multisensory Integration in Macaque Visual Cortex Depends on Cue Reliability},
    url = {http://dx.doi.org/10.1016/j.neuron.2008.06.024},
    volume = {59},
    year = {2008}
}

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Morgan et al. studied the neural responses to visual and vestibular self-motion cues in the dorsal portion of the medial superior temporal area (MSTd).

They presented congruent and incongruent stimuli at different levels of reliability and found that at any given level of reliability, the neural computation underlying multi-sensory integration could be described well by a linear addition rule.

However, the weights used in combining the uni-sensory responses changed with cue reliability.

Studies of single-neuron responses to multisensory stimuli have usually not explored the full dynamic range of inputs---they often have used near- or subthreshold stimulus intensities and thus usually found superadditive effects.

Studies of single-neuron responses to multisensory stimuli have over-emphasized the prevalence of superadditivity over that of subadditivity.