Show Reference: "Identity of a pathway for saccadic suppression"

Identity of a pathway for saccadic suppression Proceedings of the National Academy of Sciences, Vol. 104, No. 16. (17 April 2007), pp. 6824-6827, doi:10.1073/pnas.0701934104 by Psyche H. Lee, Thongchai Sooksawate, Yuchio Yanagawa, et al.
    abstract = {Neurons in the superficial gray layer ({SGS}) of the superior colliculus receive visual input and excite intermediate layer ({SGI}) neurons that play a critical role in initiating rapid orienting movements of the eyes, called saccades. In the present study, two types of experiments demonstrate that a population of {SGI} neurons gives rise to a reciprocal pathway that inhibits neurons in {SGS}. First, in {GAD67}-{GFP} knockin mice, {GABAergic} {SGI} neurons that expressed {GFP} fluorescence were injected with the tracer biocytin to reveal their axonal projections. Axons arising from {GFP}-positive neurons in {SGI} terminated densely in {SGS}. Next, {SGI} neurons in rats and mice were stimulated by using the photolysis of caged glutamate, and in vitro whole-cell patch-clamp recordings were used to measure the responses evoked in {SGS} cells. Large, synaptically mediated outward currents were evoked in {SGS} neurons. These currents were blocked by gabazine, confirming that they were {GABAA} receptor-mediated inhibitory postsynaptic currents. This inhibitory pathway from {SGI} transiently suppresses visual activity in {SGS}, which in turn could have multiple effects. These effects could include reduction of perceptual blurring during saccades as well as prevention of eye movements that might be spuriously triggered by the sweep of the visual field across the retina.},
    author = {Lee, Psyche H. and Sooksawate, Thongchai and Yanagawa, Yuchio and Isa, Kaoru and Isa, Tadashi and Hall, William C.},
    citeulike-article-id = {1284413},
    citeulike-linkout-0 = {},
    citeulike-linkout-1 = {},
    citeulike-linkout-2 = {},
    citeulike-linkout-3 = {},
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    day = {17},
    doi = {10.1073/pnas.0701934104},
    issn = {1091-6490},
    journal = {Proceedings of the National Academy of Sciences},
    keywords = {biology, deep-sc, saccades, sc, sc-connectivity, superficial-sc, suppression},
    month = apr,
    number = {16},
    pages = {6824--6827},
    pmid = {17420449},
    posted-at = {2015-01-07 15:58:03},
    priority = {2},
    publisher = {National Academy of Sciences},
    title = {Identity of a pathway for saccadic suppression},
    url = {},
    volume = {104},
    year = {2007}

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There are inhibitory connections from deep SC to superficial SC (SGI to SGS).