Show Reference: "Spatial receptive field organization of multisensory neurons and its impact on multisensory interactions"

Spatial receptive field organization of multisensory neurons and its impact on multisensory interactions Hearing Research, Vol. 258, No. 1-2. (December 2009), pp. 47-54 by Juliane Krueger, David W. Royal, Matthew C. Fister, Mark T. Wallace
@article{krueger-et-al-2009,
    abstract = {Previous work has established that the spatial receptive fields ({SRFs}) of multisensory neurons in the cerebral cortex are strikingly heterogeneous, and that {SRF} architecture plays an important deterministic role in sensory responsiveness and multisensory integrative capacities. The initial part of this contribution serves to review these findings detailing the key features of {SRF} organization in cortical multisensory populations by highlighting work from the cat anterior ectosylvian sulcus ({AES}). In addition, we have recently conducted parallel studies designed to examine {SRF} architecture in the classic model for multisensory studies, the cat superior colliculus ({SC}), and we present some of the preliminary observations from the {SC} here. An examination of individual {SC} neurons revealed marked similarities between their unisensory (i.e., visual and auditory) {SRFs}, as well as between these unisensory {SRFs} and the multisensory {SRF}. Despite these similarities within individual neurons, different {SC} neurons had {SRFs} that ranged from a single area of greatest activation (hot spot) to multiple and spatially discrete hot spots. Similar to cortical multisensory neurons, the interactive profile of {SC} neurons was correlated strongly to {SRF} architecture, closely following the principle of inverse effectiveness. Thus, large and often superadditive multisensory response enhancements were typically seen at {SRF} locations where visual and auditory stimuli were weakly effective. Conversely, subadditive interactions were seen at {SRF} locations where stimuli were highly effective. Despite the unique functions characteristic of cortical and subcortical multisensory circuits, our results suggest a strong mechanistic interrelationship between {SRF} microarchitecture and integrative capacity.},
    author = {Krueger, Juliane and Royal, David W. and Fister, Matthew C. and Wallace, Mark T.},
    citeulike-article-id = {13379128},
    citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/19698773},
    citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=19698773},
    issn = {1878-5891},
    journal = {Hearing Research},
    keywords = {aes, biology, multisensory, receptive-fields, sc},
    month = dec,
    number = {1-2},
    pages = {47--54},
    pmid = {19698773},
    posted-at = {2014-10-01 08:10:49},
    priority = {2},
    title = {Spatial receptive field organization of multisensory neurons and its impact on multisensory interactions},
    url = {http://view.ncbi.nlm.nih.gov/pubmed/19698773},
    volume = {258},
    year = {2009}
}

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Multisensory neurons in AES are mostly located at the borders of unisensory regions.

Multisensory AES cell receptive fields are not well-delineated regions in space in which and only in which a stimulus evokes a stereotyped response. Instead, they can have a region, or multiple regions, where they respond vigorously and others, surrounding those `hot spots', which in which the response is less strong.

AES neurons show an interesting form of the principle of inverse effectiveness: Cross-sensory in regions in which the unisensory component stimuli would evoke only a moderate response produce additive (or, superadditive?) responses. In contrast, Cross-sensory stimuli at the `hot spots' of a neuron tend to produce sub-additive responses.

In some SC neurons, receptive fields are not in spatial register across modalities.

Receptive fields of SC neurons in different modalities tend to overlap.

Multisensory SC cell receptive fields are not well-delineated regions in space in which and only in which a stimulus evokes a stereotyped response. Instead, they can have a region, or multiple regions, where they respond vigorously and others, surrounding those `hot spots', which in which the response is less strong.

AES integrates audio-visual inputs similar to SC.