@article{krueger-et-al-2009,
abstract = {Previous work has established that the spatial receptive fields ({SRFs}) of multisensory neurons in the cerebral cortex are strikingly heterogeneous, and that {SRF} architecture plays an important deterministic role in sensory responsiveness and multisensory integrative capacities. The initial part of this contribution serves to review these findings detailing the key features of {SRF} organization in cortical multisensory populations by highlighting work from the cat anterior ectosylvian sulcus ({AES}). In addition, we have recently conducted parallel studies designed to examine {SRF} architecture in the classic model for multisensory studies, the cat superior colliculus ({SC}), and we present some of the preliminary observations from the {SC} here. An examination of individual {SC} neurons revealed marked similarities between their unisensory (i.e., visual and auditory) {SRFs}, as well as between these unisensory {SRFs} and the multisensory {SRF}. Despite these similarities within individual neurons, different {SC} neurons had {SRFs} that ranged from a single area of greatest activation (hot spot) to multiple and spatially discrete hot spots. Similar to cortical multisensory neurons, the interactive profile of {SC} neurons was correlated strongly to {SRF} architecture, closely following the principle of inverse effectiveness. Thus, large and often superadditive multisensory response enhancements were typically seen at {SRF} locations where visual and auditory stimuli were weakly effective. Conversely, subadditive interactions were seen at {SRF} locations where stimuli were highly effective. Despite the unique functions characteristic of cortical and subcortical multisensory circuits, our results suggest a strong mechanistic interrelationship between {SRF} microarchitecture and integrative capacity.},
author = {Krueger, Juliane and Royal, David W. and Fister, Matthew C. and Wallace, Mark T.},
citeulike-article-id = {13379128},
citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/19698773},
citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=19698773},
issn = {1878-5891},
journal = {Hearing Research},
keywords = {aes, biology, multisensory, receptive-fields, sc},
month = dec,
number = {1-2},
pages = {47--54},
pmid = {19698773},
posted-at = {2014-10-01 08:10:49},
priority = {2},
title = {Spatial receptive field organization of multisensory neurons and its impact on multisensory interactions},
url = {http://view.ncbi.nlm.nih.gov/pubmed/19698773},
volume = {258},
year = {2009}
}
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Multisensory neurons in AES are mostly located at the borders of unisensory regions.⇒
Multisensory AES cell receptive fields are not well-delineated regions in space in which and only in which a stimulus evokes a stereotyped response. Instead, they can have a region, or multiple regions, where they respond vigorously and others, surrounding those `hot spots', which in which the response is less strong.⇒
AES neurons show an interesting form of the principle of inverse effectiveness: Cross-sensory in regions in which the unisensory component stimuli would evoke only a moderate response produce additive (or, superadditive?) responses. In contrast, Cross-sensory stimuli at the `hot spots' of a neuron tend to produce sub-additive responses.⇒
In some SC neurons, receptive fields are not in spatial register across modalities.⇒
Receptive fields of SC neurons in different modalities tend to overlap.⇒
Multisensory SC cell receptive fields are not well-delineated regions in space in which and only in which a stimulus evokes a stereotyped response. Instead, they can have a region, or multiple regions, where they respond vigorously and others, surrounding those `hot spots', which in which the response is less strong.⇒
AES integrates audio-visual inputs similar to SC.⇒