# Show Reference: "Mapping the Structural Core of Human Cerebral Cortex"

Mapping the Structural Core of Human Cerebral Cortex PLoS Biology, Vol. 6, No. 7. (1 July 2008), e159, doi:10.1371/journal.pbio.0060159 by Patric Hagmann, Leila Cammoun, Xavier Gigandet, et al.
@article{hagmann-et-al-2008,
abstract = {Structurally segregated and functionally specialized regions of the human cerebral cortex are interconnected by a dense network of cortico-cortical axonal pathways. By using diffusion spectrum imaging, we noninvasively mapped these pathways within and across cortical hemispheres in individual human participants. An analysis of the resulting large-scale structural brain networks reveals a structural core within posterior medial and parietal cerebral cortex, as well as several distinct temporal and frontal modules. Brain regions within the structural core share high degree, strength, and betweenness centrality, and they constitute connector hubs that link all major structural modules. The structural core contains brain regions that form the posterior components of the human default network. Looking both within and outside of core regions, we observed a substantial correspondence between structural connectivity and resting-state functional connectivity measured in the same participants. The spatial and topological centrality of the core within cortex suggests an important role in functional integration. In the human brain, neural activation patterns are shaped by the underlying structural connections that form a dense network of fiber pathways linking all regions of the cerebral cortex. Using diffusion imaging techniques, which allow the noninvasive mapping of fiber pathways, we constructed connection maps covering the entire cortical surface. Computational analyses of the resulting complex brain network reveal regions of cortex that are highly connected and highly central, forming a structural core of the human brain. Key components of the core are portions of posterior medial cortex that are known to be highly activated at rest, when the brain is not engaged in a cognitively demanding task. Because we were interested in how brain structure relates to brain function, we also recorded brain activation patterns from the same participant group. We found that structural connection patterns and functional interactions between regions of cortex were significantly correlated. Based on our findings, we suggest that the structural core of the brain may have a central role in integrating information across functionally segregated brain regions.},
author = {Hagmann, Patric and Cammoun, Leila and Gigandet, Xavier and Meuli, Reto and Honey, Christopher J. and Wedeen, Van J. and Sporns, Olaf},
citeulike-article-id = {2949792},
day = {1},
doi = {10.1371/journal.pbio.0060159},
issn = {1545-7885},
journal = {PLoS Biology},
keywords = {biology, cortex, human},
month = jul,
number = {7},
pages = {e159+},
pmcid = {PMC2443193},
pmid = {18597554},
posted-at = {2014-06-01 17:49:01},
priority = {2},
publisher = {Public Library of Science},
title = {Mapping the Structural Core of Human Cerebral Cortex},
url = {http://dx.doi.org/10.1371/journal.pbio.0060159},
volume = {6},
year = {2008}
}