Show Reference: "Excitatory Synaptic Feedback from the Motor Layer to the Sensory Layers of the Superior Colliculus"

Excitatory Synaptic Feedback from the Motor Layer to the Sensory Layers of the Superior Colliculus The Journal of Neuroscience, Vol. 34, No. 20. (14 May 2014), pp. 6822-6833, doi:10.1523/jneurosci.3137-13.2014 by Nima Ghitani, Peter O. Bayguinov, Corinne R. Vokoun, et al.
@article{ghitani-et-al-2014,
    abstract = {Neural circuits that translate sensory information into motor commands are organized in a feedforward manner converting sensory information into motor output. The superior colliculus ({SC}) follows this pattern as it plays a role in converting visual information from the retina and visual cortex into motor commands for rapid eye movements (saccades). Feedback from movement to sensory regions is hypothesized to play critical roles in attention, visual image stability, and saccadic suppression, but in contrast to feedforward pathways, motor feedback to sensory regions has received much less attention. The present study used voltage imaging and patch-clamp recording in slices of rat {SC} to test the hypothesis of an excitatory synaptic pathway from the motor layers of the {SC} back to the sensory superficial layers. Voltage imaging revealed an extensive depolarization of the superficial layers evoked by electrical stimulation of the motor layers. A pharmacologically isolated excitatory synaptic potential in the superficial layers depended on stimulus strength in the motor layers in a manner consistent with orthodromic excitation. Patch-clamp recording from neurons in the sensory layers revealed excitatory synaptic potentials in response to glutamate application in the motor layers. The location, size, and morphology of responsive neurons indicated they were likely to be narrow-field vertical cells. This excitatory projection from motor to sensory layers adds an important element to the circuitry of the {SC} and reveals a novel feedback pathway that could play a role in enhancing sensory responses to attended targets as well as visual image stabilization. Copyright {\copyright} 2014 the authors 0270-6474/14/346822-12\$15.00/0.},
    author = {Ghitani, Nima and Bayguinov, Peter O. and Vokoun, Corinne R. and McMahon, Shane and Jackson and Basso, Michele A.},
    citeulike-article-id = {13171061},
    citeulike-linkout-0 = {http://dx.doi.org/10.1523/jneurosci.3137-13.2014},
    citeulike-linkout-1 = {http://www.jneurosci.org/content/34/20/6822.abstract},
    citeulike-linkout-2 = {http://www.jneurosci.org/content/34/20/6822.full.pdf},
    citeulike-linkout-3 = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019797/},
    citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/24828636},
    citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=24828636},
    day = {14},
    doi = {10.1523/jneurosci.3137-13.2014},
    issn = {1529-2401},
    journal = {The Journal of Neuroscience},
    keywords = {biology, deep-sc, sc, sc-connectivity, superficial-sc},
    month = may,
    number = {20},
    pages = {6822--6833},
    pmcid = {PMC4019797},
    pmid = {24828636},
    posted-at = {2015-01-07 15:43:30},
    priority = {2},
    publisher = {Society for Neuroscience},
    title = {Excitatory Synaptic Feedback from the Motor Layer to the Sensory Layers of the Superior Colliculus},
    url = {http://dx.doi.org/10.1523/jneurosci.3137-13.2014},
    volume = {34},
    year = {2014}
}

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There are excitatory and inhibitory connections from the deep to the superficial SC.

The excitatory and inhibitory connections from the deep to the superficial SC and the connection from the superficial SC to LGN may be one route through which deep SC activity may reach cortex.