Show Reference: "Functional connectivity between the superficial and deeper layers of the superior colliculus: an anatomical substrate for sensorimotor integration."

Functional connectivity between the superficial and deeper layers of the superior colliculus: an anatomical substrate for sensorimotor integration. The Journal of Neuroscience, Vol. 23, No. 16. (23 July 2003), pp. 6596-6607 by Timothy P. Doubell, Irini Skaliora, Jérôme Baron, Andrew J. King
@article{doubell-et-al-2003,
abstract = {The superior colliculus ({SC}) transforms both visual and nonvisual sensory signals into motor commands that control orienting behavior. Although the afferent and efferent connections of this midbrain nucleus have been well characterized, little is know about the intrinsic circuitry involved in sensorimotor integration. Transmission of visual signals from the superficial ({sSC}) to the deeper layers ({dSC}) of the {SC} has been implicated in both the triggering of orienting movements and the activity-dependent processes that align maps of different sensory modalities during development. However, evidence for the synaptic connectivity appropriate for these functions is lacking. In this study, we used a variety of anatomical and physiological methods to examine the functional organization of the {sSC}-{dSC} pathway in juvenile and adult ferrets. Axonal tracing in adult ferrets showed that, as in other species, {sSC} neurons project topographically to the {dSC}, providing a route for the transmission of visual signals to the multisensory output layers of the {SC}. We found that {sSC} axons terminate on {dSC} neurons that stain prominently for the {NR1} subunit of the {NMDA} receptor, a subpopulation of which were identified as tectoreticulospinal projection neurons. We also show that the {sSC}-{dSC} pathway is topographically organized and mediated by monosynaptic excitatory synapses even before eye opening in young ferrets, suggesting that visual signals routed via the {sSC} may influence the activity of {dSC} neurons before the emergence of their multisensory response properties. These findings indicate that superficial- to deep-layer projections provide spatially ordered visual signals, both during development and into adulthood, directly to {SC} neurons that are involved in coordinating sensory inputs with motor outputs.},
author = {Doubell, Timothy P. and Skaliora, Irini and Baron, J\'{e}r\^{o}me and King, Andrew J.},
day = {23},
issn = {1529-2401},
journal = {The Journal of Neuroscience},
keywords = {auditory, biology, ic, icx, multi-modality, sc, sc-ic-feedback, sc-input},
month = jul,
number = {16},
pages = {6596--6607},
pmid = {12878701},
posted-at = {2012-08-20 13:25:03},
priority = {2},
title = {Functional connectivity between the superficial and deeper layers of the superior colliculus: an anatomical substrate for sensorimotor integration.},
url = {http://view.ncbi.nlm.nih.gov/pubmed/12878701},
volume = {23},
year = {2003}
}