Show Reference: "Defense-Like Behaviors Evoked by Pharmacological Disinhibition of the Superior Colliculus in the Primate"

Defense-Like Behaviors Evoked by Pharmacological Disinhibition of the Superior Colliculus in the Primate The Journal of Neuroscience, Vol. 33, No. 1. (02 January 2013), pp. 150-155, doi:10.1523/jneurosci.2924-12.2013 by Jacqueline T. DesJardin, Angela L. Holmes, Patrick A. Forcelli, et al.
@article{desjardin-et-al-2013,
    abstract = {Stimulation of the intermediate and deep layers of superior colliculus ({DLSC}) in rodents evokes both orienting/pursuit (approach) and avoidance/flight (defense) responses (Dean et al., 1989). These two classes of response are subserved by distinct output projections associated with lateral (approach) and medial (defense) {DLSC} (Comoli et al., 2012). In non-human primates, {DLSC} has been examined only with respect to orienting/approach behaviors, especially eye movements, and defense-like behaviors have not been reported. Here we examined the profile of behavioral responses evoked by activation of {DLSC} by unilateral intracerebral infusions of the {GABAA} receptor antagonist, bicuculline methiodide ({BIC}), in nine freely moving macaques. Across animals, the most consistently evoked behavior was cowering (all animals), followed by increased vocalization and escape-like behaviors (seven animals), and attack of objects (three animals). The effects of {BIC} were dose-dependent within the range 2.5–14 nmol (threshold dose of 4.6 nmol). The behaviors and their latencies to onset did not vary across different infusion sites within {DLSC}. Cowering and escape-like behaviors resembled the defense-like responses reported after {DLSC} stimulation in rats, but in the macaques these responses were evoked from both medial and lateral sites within {DLSC}. Our findings are unexpected in the context of an earlier theoretical perspective (Dean et al., 1989) that emphasized a preferential role of the primate {DLSC} for approach rather than defensive responses. Our data provide the first evidence for induction of defense-like behaviors by activation of {DLSC} in monkeys, suggesting that the role of {DLSC} in responding to threats is conserved across species.},
    author = {DesJardin, Jacqueline T. and Holmes, Angela L. and Forcelli, Patrick A. and Cole, Claire E. and Gale, John T. and Wellman, Laurie L. and Gale, Karen and Malkova, Ludise},
    day = {02},
    doi = {10.1523/jneurosci.2924-12.2013},
    issn = {1529-2401},
    journal = {The Journal of Neuroscience},
    keywords = {body-movements, motor, sc},
    month = jan,
    number = {1},
    pages = {150--155},
    pmid = {23283329},
    posted-at = {2013-01-03 15:36:53},
    priority = {2},
    publisher = {Society for Neuroscience},
    title = {{Defense-Like} Behaviors Evoked by Pharmacological Disinhibition of the Superior Colliculus in the Primate},
    url = {http://dx.doi.org/10.1523/jneurosci.2924-12.2013},
    volume = {33},
    year = {2013}
}

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