Show Reference: "Cross-modal Circuitry between auditory and somatosensory areas of the cat anterior ectosylvian sulcal cortex: A 'New' Inhibitory form of Multisensory Convergence"

Cross-modal Circuitry between auditory and somatosensory areas of the cat anterior ectosylvian sulcal cortex: A 'New' Inhibitory form of Multisensory Convergence Cerebral Cortex, Vol. 14, No. 4. (April 2004), pp. 387-403 by Lisa R. Dehner, Leslie P. Keniston, Ruth R. Clemo, Alex A. Meredith
@article{dehner-et-al-2004,
    abstract = {Examples of convergence of visual and auditory, or visual and somatosensory, inputs onto individual neurons abound throughout the brain, but substantially fewer incidences of auditory-somatosensory neurons have been reported. The present experiments sought to examine auditory-somatosensory convergence to assess whether there is a feature of this type of convergence that might obscure it from conventional methods of multisensory detection. Auditory-somatosensory convergence was explored in cat anterior ectosylvian sulcus ({AES}) cortex, where higher-order somatosensory area {IV} ({SIV}) and auditory field of the anterior ectosylvian sulcus ({FAES}) share a common border. While neuroanatomical tracers documented a projection from {FAES} to {SIV}, physiological studies failed to reveal the bimodal neurons expected from such cross-modal connectivity. Stimulation of {FAES} through indwelling electrodes also failed to excite any of the {SIV} neurons examined. However, when stimulation of auditory {FAES} was combined with somatosensory stimulation, a large majority (66\%) of {SIV} neurons showed a significant response attenuation. {FAES}-induced response suppression was specific to {SIV}, could not be elicited by activating other auditory regions and was blocked by the microiontophoretic application of the {GABAergic} antagonist bicuculline methiodide. Based on these data, a novel, cross-modal circuit is proposed involving projections from auditory {FAES} to somatosensory {SIV}, where local inhibitory interneurons 'reverse the sign' of the cross-modal signals to produce auditory-somatosensory suppression. This form of excitatory-inhibitory multisensory convergence has not been reported before and suggests that the level of interaction between auditory and somatosensory modalities has been substantially underestimated.},
    author = {Dehner, Lisa R. and Keniston, Leslie P. and Clemo, Ruth R. and Meredith, Alex A.},
    citeulike-article-id = {13375118},
    citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/15028643},
    citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=15028643},
    issn = {1047-3211},
    journal = {Cerebral Cortex},
    keywords = {aes, attention, sc-input},
    location = {New York},
    month = apr,
    number = {4},
    pages = {387--403},
    pmid = {15028643},
    posted-at = {2014-09-26 13:30:16},
    priority = {2},
    publisher = {Oxford University Press},
    title = {Cross-modal Circuitry between auditory and somatosensory areas of the cat anterior ectosylvian sulcal cortex: A `New' Inhibitory form of Multisensory Convergence},
    url = {http://view.ncbi.nlm.nih.gov/pubmed/15028643},
    volume = {14},
    year = {2004}
}

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SIV neurons are excited almost exclusively by somatosensory stimuli.

SIV neurons' activity can be inhibited by activity in the auditory FAES.

The function of SIV is unknown.

Dehner et al. speculate that the inhibitory influence of FAES activity on SIV activity is connected to modality-specific attention: According to that hypothesis, an auditory stimulus which leads to strong FAES activity will suppress activity in FAES and thus block out cortical somatosensory input to the SC.