Show Reference: "A computational study of multisensory maturation in the superior colliculus ({SC})"

A computational study of multisensory maturation in the superior colliculus (SC) Experimental Brain Research, Vol. 213, No. 2. (1 September 2011), pp. 341-349, doi:10.1007/s00221-011-2714-z by Cristiano Cuppini, Barry E. Stein, Benjamin A. Rowland, Elisa Magosso, Mauro Ursino
    abstract = {Multisensory neurons in cat {SC} exhibit significant postnatal maturation. The first multisensory neurons to appear have large receptive fields ({RFs}) and cannot integrate information across sensory modalities. During the first several months of postnatal life {RFs} contract, responses become more robust and neurons develop the capacity for multisensory integration. Recent data suggest that these changes depend on both sensory experience and active inputs from association cortex. Here, we extend a computational model we developed (Cuppini et al. in Front Integr Neurosci 22: 4–6, 2010) using a limited set of biologically realistic assumptions to describe how this maturational process might take place. The model assumes that during early life, {cortical-SC} synapses are present but not active and that responses are driven by non-cortical inputs with very large {RFs}. Sensory experience is modeled by a  training phase  in which the network is repeatedly exposed to modality-specific and cross-modal stimuli at different locations. {Cortical-SC} synaptic weights are modified during this period as a result of Hebbian rules of potentiation and depression. The result is that {RFs} are reduced in size and neurons become capable of responding in adult-like fashion to modality-specific and cross-modal stimuli. Supported by {NIH} grants {NS036916} and {EY016716}.},
    author = {Cuppini, Cristiano and Stein, Barry E. and Rowland, Benjamin A. and Magosso, Elisa and Ursino, Mauro},
    day = {1},
    doi = {10.1007/s00221-011-2714-z},
    issn = {0014-4819},
    journal = {Experimental Brain Research},
    month = sep,
    number = {2},
    pages = {341--349},
    posted-at = {2011-07-27 16:23:58},
    priority = {3},
    publisher = {Springer Berlin / Heidelberg},
    title = {A computational study of multisensory maturation in the superior colliculus ({SC})},
    url = {},
    volume = {213},
    year = {2011}

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The model due to Cuppini et al. develops low-level multisensory integration (spatial principle) such that integration happens only with higher-level input.

In their model, Hebbian learning leads to sharpening of receptive fields, overlap of receptive fields, and Integration through higher-cognitive input.