Show Reference: "Multisensory Integration in the Superior Colliculus Requires Synergy among Corticocollicular Inputs"

Multisensory Integration in the Superior Colliculus Requires Synergy among Corticocollicular Inputs The Journal of Neuroscience, Vol. 29, No. 20. (20 May 2009), pp. 6580-6592, doi:10.1523/jneurosci.0525-09.2009 by Juan C. C. Alvarado, Terrence R. Stanford, Benjamin A. Rowland, William W. Vaughan, Barry E. Stein
@article{alvarado-et-al-2009,
    abstract = {Influences from the visual ({AEV}), auditory ({FAES}), and somatosensory ({SIV}) divisions of the cat anterior ectosylvian sulcus ({AES}) play a critical role in rendering superior colliculus ({SC}) neurons capable of multisensory integration. However, it is not known whether this is accomplished via their independent sensory-specific action or via some cross-modal cooperative action that emerges as a consequence of their convergence on {SC} neurons. Using visual-auditory {SC} neurons as a model, we examined how selective and combined deactivation of {FAES} and {AEV} affected {SC} multisensory (visual-auditory) and unisensory (visual-visual) integration capabilities. As noted earlier, multisensory integration yielded {SC} responses that were significantly greater than those evoked by the most effective individual component stimulus. This multisensory "response enhancement" was more evident when the component stimuli were weakly effective. Conversely, unisensory integration was dominated by the lack of response enhancement. During cryogenic deactivation of {FAES} and/or {AEV}, the unisensory responses of {SC} neurons were only modestly affected; however, their multisensory response enhancement showed a significant downward shift and was eliminated. The shift was similar in magnitude for deactivation of either {AES} subregion and, in general, only marginally greater when both were deactivated simultaneously. These data reveal that {SC} multisensory integration is dependent on the cooperative action of distinct subsets of unisensory corticofugal afferents, afferents whose sensory combination matches the multisensory profile of their midbrain target neurons, and whose functional synergy is specific to rendering {SC} neurons capable of synthesizing information from those particular senses.},
    author = {Alvarado, Juan C. C. and Stanford, Terrence R. and Rowland, Benjamin A. and Vaughan, William W. and Stein, Barry E.},
    day = {20},
    doi = {10.1523/jneurosci.0525-09.2009},
    issn = {1529-2401},
    journal = {The Journal of Neuroscience},
    keywords = {auditory, biology, cue-combination, enhancement, inhibition, multi-modality},
    month = may,
    number = {20},
    pages = {6580--6592},
    pmcid = {PMC2805025},
    pmid = {19458228},
    posted-at = {2012-08-10 16:35:32},
    priority = {2},
    title = {Multisensory Integration in the Superior Colliculus Requires Synergy among Corticocollicular Inputs},
    url = {http://dx.doi.org/10.1523/jneurosci.0525-09.2009},
    volume = {29},
    year = {2009}
}

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